Delayed Hypersensitivity: Specific Cell-mediated Immunity

Cell-mediated immunity: delayed-type hypersensitivity and cytotoxic responses are mediated by different T-cell subclasses

Cell-mediated immunity includes both the generation of cytotoxic cells and initiation of delayed-type hypersensitivity (DTH). The resting T-cell population, before stimulation by antigen, already contains cells of the Lyl subclass that are programmed to initiate DTH (and helper function) but not cytotoxic responses, as well as Ly23 cells which can generate killer activity (and suppressive funct...

Cell-mediated immunity in ferrets. Delayed dermal hypersensitivity, lymphocyte transformation, and macrophage migration inhibitory factor production.

Cell-mediated immune reactions delayed dermal hypersensitivity, lymphocyte transformation, and macrophage migration inhibitory factor production were investigated in the ferret. Ferrets immunized with streptokinase in complete Freund's adjuvant had skin test responses characterized by induration with little erythema; skin test biopsies showed mononuclear cell infiltration. In vitro transformati...

Staphylokinase-specific cell-mediated immunity in humans.

Staphylokinase is a highly fibrin-specific clot-dissolving agent that constitutes a promising drug for clinical development. It is of bacterial origin, and the majority of patients develop neutralizing Ab after its administration. Several antigenic regions, recognized by these Ab, have been identified, but the underlying immunogenic features of staphylokinase remain unknown. In this study, we s...

Cell Reactions in Delayed Hypersensitivity

EVALUATION OF CELL-MEDIATED IMMUNITY IN MUSTARD GAS INJURIES

Yamakido, et al. in 1986 have studied immunological parameters in poison gas workers, and a depression has been observed in immunologic response. Also, the frequency of cancer has reached as high as five-fold that of the general population. In the present study, cell-mediated immunity (CMI) was measured in three groups of Iranian mustard gas-injured patients. The first group were those wh...